Play 28 · Health and life sciences
The antibody in your last three papers is discontinued
A seven-step play for a research reagent supplier. It starts from PubMed, stacks Firecrawl, NIH RePORTER and Europe PMC on top, and ends in a message to the principal investigator that is useful before anyone replies.
Installs this workflow, five project tables and a draft campaign. Source access and any external outputs are checked before research.
- Category
- Health and life sciences
- Sources
- 4
- Steps
- 7
The workflow
- Trigger
PubMedCatalog and clone numbers in methods sections - Evidence
- ArtifactWhat you hand overA validated equivalent with side-by-side data on the same tissue, and the papers that already use it.
- ContactGliderFinds the principal investigator, with a verified work email and a phone
- MessageSend itFrom your own mailboxes, evidence attached
Why it earns attention
A lab that built years of work on one antibody clone cannot just switch. When that product is retired, they need a validated replacement before their stock runs out, and few suppliers will tell them.
The play in seven steps
- 01
Find who uses the antibody
PubMed- What you pull
- Methods sections that cite a specific catalog number or clone: the paper, the lab, and the application. Europe PMC adds full text for more labs.
- Why it matters
- A lab that used the same clone in three papers depends on it. That is the lab that has to act.
ExampleClone X · catalog 1234 · cited in 3 papers from one lab · immunohistochemistry on mouse liver
- 02
Confirm it was discontinued
Firecrawl- What you pull
- The supplier's product page and notices: status, the date it was retired, and any suggested alternative.
- Why it matters
- This is the trigger. Labs often learn about it when an order bounces.
ExampleDiscontinued Sept 2026 · supplier suggests a different clone
- 03
Check they have years of work left
NIH RePORTER- What you pull
- The PI's active grants: end dates and aims that use the same application.
- Why it matters
- Funding through 2028 means two more years of experiments on that clone. That is the size of the problem.
ExampleR01 active through 2028 · aim 2 uses the same staining
- 04
Build the replacement pack
Your artifact- What you build
- Your equivalent with validation data on the same tissue and application, side by side with the retired product, and papers that already use it.
- Why it works
- A PI won't swap a reagent on a promise. Comparison data on their own tissue type is the only thing that works.
ExampleSame epitope · IHC on mouse liver · matching staining pattern · cited in 7 papers
- 05
Check before you send
Only claim equivalence you have data for. If you lack validation on their tissue or application, offer a free test vial instead.
- 06
Find the principal investigator in Glider
Glider- Search for
- Principal investigatorLab managerPostdoctoral researcherResearch technician
- Why them
- The PI decides; the lab manager orders and will notice the empty shelf first.
- What you get
- A work email and a direct phone, with the email verified before it goes into a sequence.
- 07
Send the evidence, then run the first test
To: the principal investigatorEvery line comes from a step above Your last three papers used clone X under catalog 1234,1 which the supplier retired in September.2 Your R01 runs through 2028 and aim 2 uses the same staining.3 Here's our equivalent with side-by-side IHC data on mouse liver, the tissue you work with.4 Can I send a test vial?
- Facts from the data (the number is the step)
- What you built for them
- One small ask
- Why it works
- It is about their reagent and their papers, it names a problem they will hit soon, and the ask is a free test, not a purchase.
- First test
- One discontinued reagent, twenty labs with recent citations and active funding.
- Success looks like
- Five test vials sent out of twenty labs, and two orders.
The sample message is hypothetical and its numbers are illustrative. Verify every claim, date and rule before sending.
Sources used
The four sources this play names. Each links to the other plays that use it.
Related plays
All 63 GTM playsRun this play with Glider.
Deploy the full workflow into a project. Conway checks your scope and source access, builds the evidence, and prepares outreach for review.